Huang Bin, Xu Aifang, et al. Chin J Hepatol, 2019, 27(6)

•To evaluate the using value of FibroTouch and six serological models in detecting the degree of liver fibrosis in CHB patients.
•Attempt to provide reference for accurate diagnosis.

•258 CHB patients.
•All patients underwent liver histopathological examination and FibroTouch measurement to determine liver stiffness (LSM).
•Serum biochemical parameters were detected and the scoring values of six serological models were calculated.

•The median LSM of 258 cases with CHB was 9.4 (6.5-13.8) kPa. In the six serological models, the median value of APRI, FIB-4 index, S-index, Forns index, PRP index, and FIB-5 were 0.42 (0.28-0.62), 1.27 (0.78-2.03), 0.11 (0.07-0.20), 6.95 (5.89-8.51), 0.0008 (0.0006-0.0009), and 38.59 (36.28-40.97).
•FibroTouch had positive correlation with APRI, FIB-4, S-index, Forns index, PRP, fibrosis stage (r = 0.73, P < 0.001) and inflammation grade, and had negative correlation with FIB-5, and both had statistical significance.
•The AUC of FT-LSM at S ≥ 2, S ≥ 3, S = 4 were 0.89,0.90 and 0.85, respectively, which was significantly higher than serological models (P < 0.001). The AUC of S-index model at S ≥ 2, S ≥ 3, S = 4 were higher than other five serological models.

•The diagnostic performance of FibroTouch is significantly better than serological model.
•S-index model has the best diagnostic performance in the six serological models, and the combination of S-index and FT-LSM may better diagnose the grading of liver fibrosis, and thus can be applied and promoted in clinic.