•446 CH patients combined with hepatocellular carcinoma.
•All the patients were divided into the index cohort (n = 288) and the validated cohort (n = 158).
•All patients were diagnosed with hepatic fibrosis by pathological criteria (S0 to S4) .
•At the same time, preoperative FibroTouch imaging was performed, ROC evaluation was used to detect FibroTouch imaging diagnosis of liver fibrosis degree of sensitivity and specific degrees of chronic hepatitis B with liver cancer patients.

•According to the liver fibrosis grading criterion, index cohort included S0 (n = 35), S1 (n = 47), S2 (n = 83), S3 (n = 37) and S4 (n = 86); the validated cohort includes S0 (n = 27), S1 (n = 18), S2 (n = 45), S3 (n = 16) and S4 (n = 53).
•According to the diagnosis of FibroTouch imaging, in the index cohort, the area under ROC curve of non or mild liver fibrosis (S0/S1), significant liver fibrosis (S2/S3/S4), severe liver fibrosis (S3/S4) and liver cirrhosis (S4) were 0.89 (95% CI 0.85 to 0.93) , 0.86 (95% CI 0.82 to 0.90), 0.84 (95% CI 0.80 to 0.88) and 0.85 (95% CI 0.81 to 0.89), respectively; in the validated cohort were 0.94 (95% CI 0.90 to 0.97), 0.91 (95% CI 0.86 to 0.95), 0.87 (95% CI 0.81 to 0.92) and 0.86 (95% CI 0.79 to 0.91), respectively.