Liu YY, Liu YP, et al. J Clin Hepatol. 2020:36(11).

•To evaluate the intervention effect of moderate intensity aerobic exercise on patients with metabolic-associated fatty liver disease (MAFLD), and to preliminarily explore the intervention program, so as to provide theoretical basis and new ideas for the effective prevention and treatment of MAFLD.

•A total of 158 patients with MAFLD were enrolled and randomly divided into control group (n = 52), monthly follow-up group (n = 54) and weekly follow-up group (n = 52).
•The control group was only given health education at the time of enrollment, while the monthly follow-up group and the weekly follow-up group both received moderate intensity aerobic exercise intervention. Both groups used exercise bracelet to monitor exercise and wechat platform for follow-up, and the follow-up frequency of the two groups was once a month and once a week respectively.
•FibroTouch, a non-invasive liver fibrosis diagnostic system, was used to detect the degree of fatty liver in MAFLD patients before and after intervention.

•Before intervention, there were no statistically significant differences in all indicators among the three groups (all P values > 0.05).
•There were no significant changes in the parameters between the blank group and the monthly follow-up group. The parameters (except GGT and UA) in the weekly follow-up group were significantly different from those in the other two groups (P < 0.05).

•Moderate-intensity aerobic exercise can significantly reduce the serum TG, ALT, GGT levels of MAFLD patients, and significantly reduce the degree of fatty liver. The effect of follow-up frequency management once a week is better than that once a month. At the same time, the remote management based on exercise bands and wechat software is simple and easy, and MAFLD patients have high acceptance.