ACADEMIC HISKY
ACADEMIC HISKY
The value of FibroTouch fat attenuation parameter in patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease
Mao Zhongshan, Shang Jia, et al. Chin J Infect Dis, 2015, 33(6)
Objective
•To explore the diagnostic value of FibroTouch fat attenuation parameter in CHB patients complicated with NAFLD.
Methods

•115 CHB patients were divided into two groups: 61 CHB only and 54 complicated with NAFLD.
•The diagnostic value and related factors of FibroTouch in liver inflammation, fibrosis and fatty liver disease were analyzed.
•Student t test was used in quantitative data analysis, and difference between groups was analyzed by using one way analysis of variance (ANOVA). The qualitative data were compared by chi-square test.

Figures & Tables
Results

•In 115 patients, the liver stiffness value was (8.22 ± 6.33) kPa, fat attenuation parameter was (242.37 ± 31.56) dB/m. The fat attenuation parameters, body mass index (BMI), total cholesterol, triacylglycerol and glucose of CHB patients with NAFLD group were higher than those of CHB group, with statistically significant differences (all P < 0.05).
•54 patients diagnosed with CHB complicated with NAFLD were divided into mild, moderate and severe subgroups according to the degree of liver fat. The fat attenuation parameter increased along with the degree of liver fat (P < 0.05).
•The sensitivity of fat attenuation parameter was 92.6% and the specificity was 85.0%. In same grades of fibrosis and inflammation, the fat attenuation parameter of patients with CHB complicated with NAFLD was higher than patients with CHB only, with statistically significant difference (P < 0.05).
•There were no statistically significant differences of fat attenuation parameter with different degree of liver inflammation (X2 = 5.901, P = 0.117) and fibrosis (X2 = 4.073, P = 0.254) in the two groups.

Conclusion
•As a new noninvasive diagnostic method, FibroTouch can reflect the degree of fat of the liver, which could be recommended as the clinical diagnosis tool for CHB complicated with NAFLD patients.
If you need more academic materials, please contact us.
Submit