Yang XM, Halimulati ABDSLM, et al. J Clin Hepatol.2020, 36(8).

•To investigate the efficiency of transient elastography (TE) in the diagnosis of liver fibrosis in patients with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection.

•A total of 76 patients with HIV and HCV co-infection confirmed by liver biopsy were enrolled.
•The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of LSM for liver fibrosis staging in patients with co-infection.

•Correlation analysis showed that LSM had the best correlation with liver fibrosis stage (r = 0.526, P < 0.001), which was better than APRI (r = 0.403, P < 0.001) and FIB-4 (r = 0.441, P < 0.001). Only type IV collagen was correlated with liver fibrosis stage (r = 0.339, P < 0.05), but there was no correlation between HCV RNA quantification and liver fibrosis stage.
•For the significant fibrosis stage, the area under the ROC curve of LSM for diagnosing S2, S3 and S4 was 0.809, 0.929 and 0.906, respectively.

•Transient elastography can accurately determine the stage of liver fibrosis in patients with HCV/HIV coinfection,which might help to avoid liver biopsy and provide a more reliable basis for developing antiviral regimen and judging the progression of liver fibrosis, and therefore, it holds promise for clinical application.