•313 CHB patients.
•All the patients underwent liver biopsy, and FT and FS were used to determine liver stiffness measurement (LSM).
•Serum biochemical parameters were measured, the APRI、FIB-4 index were calculated.
•The consistency between the results of four noninvasive examinations and Ishak fibrosis score was compared.
•Based on the Ishak fibrosis score, the ROC curve was used to analyze the values of four noninvasive methods in the diagnosis of liver fibrosis.

•There was no significant difference in LSM measured by FT and FS in all patients (15.75 ± 9.42 kPa vs 15.42 ± 10.52 kPa, P > 0.05) and Pearson correlation analysis indicated a significant positive correlation between them (r = 0.858, P < 0.01); serum ALT and AST levels and liver inflammatory activity were correlated with LSM determined by FT and FS.
•There was a significant positive correlation between LSM determined by FT and FS and fibrosis stage (r = 0.501 and 0.526, both P < 0.001), and APRI and FIB-4 were also positively correlated with fibrosis stage (r = 0.236 and 0.218, both P < 0.001).
•Based on the Ishak fibrosis score, in the diagnosis of fibrosis stages F3, F4, F5, and F6, (AUC were 0.915/0.856/0.839/0.816 for FT, 0.933/0.883/0.849/0.856 for FS, 0.618/0.630/0.608/0.638 for APRI, and 0.614/0.624/0.595/0.649 for FIB-4, and FT and FS had a significantly larger areas under the ROC curve than APRI and FIB-4.